Ribonuclease inhibitor and latent ribonuclease in rat liver during feeding of 2-acetamidofluorene.

the relationships between RNase activity and cancer, and a review concerning these relationships has been published (14). An understanding of the role of RNase in growth processes has been complicated by dernonstra tions that there is a multiplicity of RNases (14) and of intracellular inhibitors for RNase (9, 11) in animal tissues. Furthermore, the recent discovery that some samples of RNA contain impurities that interefere with the deter mination of RNase and RNase inhibitor activities (3, 18, 21) has made it clear that the RNase inhibitor is more widely distributed and occurs in considerably greater amounts than heretofore suspected. With the use of technics modified to allow complete expression of RNase